Preheat your oven to 375°F (190°C). Grease a muffin tin or line with paper liners.
In a large bowl, whisk together the flour, sugar, baking powder, and salt.
In another bowl, combine the cranberries and orange zest. Add to the flour mixture and toss to coat.
In a separate bowl, mix together the orange juice, milk, vegetable oil, vanilla extract, and beaten egg.
Pour the wet ingredients into the dry ingredients and stir until just combined. Do not overmix.
Divide the batter evenly among the muffin cups.
Bake for 20 minutes or until a toothpick inserted into the center comes out clean.
Let the muffins cool in the tin for 5 minutes, then transfer to a wire rack to cool completely.